Consultant-led education

VOD: A detailed overview, full clinical assessment of treatment with Defitelio® and case studies from clinical practice.

Prof. Antonio Pagliuca provides in-depth education on VOD and the use of Defitelio®, while Dr Manos Nikolousis presents two case studies where the principles of detecting and treating the disease were applied successfully.

Introduction to VOD

Find out about VOD and its disease pathophysiology, clinical presentation, diagnostic criteria and treatment with Defitelio®.

Prof. Antonio Pagliuca is a stem-cell transplantation specialist at King’s College Hospital, London, UK. He provides a detailed overview of VOD and a full clinical assessment of its treatment with Defitelio®.


Case studies Diagnosis and severity grading Disease fundamentals Risk assessment and monitoring Treatment


Adverse events should be reported. Reporting forms and information for the UK can be found at:

For Ireland, reporting forms and information can be found at:

Adverse events should also be reported to Jazz Pharmaceuticals at:

Defitelio® is indicated for the treatment of severe hepatic veno-occlusive disease (VOD) also known as sinusoidal obstruction syndrome (SOS) in haematopoietic stem-cell transplantation (HSCT) therapy. It is indicated in adults and in adolescents, children and infants over 1 month of age.