Consultant-led education

Severe Late-onset VOD in Clinical Practice

Dr Varun Mehra presents the case of a 68-year-old male who developed late-onset VOD at day-56 post-HSCT.


Case studies Diagnosis and severity grading Disease fundamentals Risk assessment and monitoring Treatment


Adverse events should be reported. Reporting forms and information for the UK can be found at:

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Adverse events should also be reported to Jazz Pharmaceuticals at:

Defitelio® is indicated for the treatment of severe hepatic veno-occlusive disease (VOD) also known as sinusoidal obstruction syndrome (SOS) in haematopoietic stem-cell transplantation (HSCT) therapy. It is indicated in adults and in adolescents, children and infants over 1 month of age.